This dissertation estimates the impact of two geographically targeted economic development programs on the employment of people living in the targeted areas. This question is difficult to address for a number of reasons. Unlike in most program evaluation problems, the process that determines the outcome of interest (resident employment) happens at a lower level of aggregation than the process that determines selection for treatment. Therefore, standard program evaluation techniques have to be modified to address this issue. The programs I study, the enterprise zone programs of California and Florida, were designated at a very detailed level of geography, making it hard to measure the location and the characteristics of the zones. I develop a methodology to address the unusual selection process of these programs.